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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A study compared treatment with cinacalcet versus treatment with placebo in subjects with known hyperparathyroidism. The primary outcome of the study was the proportion of study subjects with a mean intact parathyroid hormone level < 250 pg/mL. Among the cinacalcet group (n = 371), 43% of subjects achieved the primary outcome; among the placebo group (n =
370), 5% achieved the primary outcome (p<0.05).
Which of the following is the number needed to treat (NNT)?

A) 3
B) 1
C) 14
D) 8

2. A 47-year-old patient with end-stage renal disease undergoing hemodialysis has an HCT of 23% and exhibits anginal symptoms. Upon further Workup, no evidence of occult bleeding is found.
In addition to antianginal therapy, which of the following is the most appropriate initial treatment for this patient's anemia?

A) Subcutaneous erythropoietin
B) Iron dextran
C) Oral iron
D) Two units of PRBCs

3. Permission to use a previously published figure or illustration in a manuscript should be initially obtained from which of the following?

A) The editor of the journal to which the manuscript is being submitted
B) The author of the original article
C) The National Library of Medicine
D) The publisher of the journal or book containing the original figure

4. A 28 year old patient presents to a physician and reports persistent nasal discharge and facial tenderness for the past 15 days. The patient has no known drug allergies. Which recommendation would be best for treating this acute sinusitis?

A) No antimicrobial indicated at this time
B) Amoxicillin/clavulanate acid
C) Sulfamethoxazole/trimethoprim
D) Azithromycin

5. A 65-year-old man presents to the internal medicine clinic with decreased exercise tolerance, lower extremity edema, and shortness of breath.
He has a history of diastolic dysfunction (ejection fraction of 60%) and hypertension; BP =
150/90 mm Hg, HR = 86 bpm.
Current medications include digoxin 125 mcg daily, furosemide 40 mg daily, enalapril 10 mg twice daily, aspirin 325 mg daily, and potassium 10 mEq twice daily. The digoxin concentration is 0.4 ng/mL.
After resolution of this exacerbation, which of the following should the pharmacotherapy specialist recommend to the internist regarding this patient's maintenance drug therapy?

A) Discontinue digoxin and add metoprolol.
B) Discontinue digoxin and add amlodipine.
C) Increase digoxin.
D) Increase furosemide.

Solutions: